Interesting cases in Uterine and Vulvar Pathology – Post Quiz

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Elizabeth Kehr, MD, CellNetix, Tacoma

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  First Last Credentials
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• What is the incidence of isolated dVIN on biopsy? What is the incidence of dVIN associated with invasive squamous cell carcinoma?*
  • 65%; 5%
  • 5%; greater than 50%
  • 50%; 50%
  • 15%; 85%

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• What is the immunohistochemical phenotype that best characterizes dVIN ?*
  • p16 band like; p53 full thickness; ki-67 full thickness
  • p16 band like; p53 wild type; ki-67 full thickness
  • p16 negative; p53 positive basal layer; ki-67 positive basal layer
  • p16 negative, p53 wild type, ki-67 positive basal layer

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• Which vascular pattern suggests a diagnosis of IMT?*
  • Thin walled, elongated vessels
  • Thick walled vessels
  • Thin walled, small circular vessels
  • Hemangiopericytoma like vessels

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• What morphologic findings are most sensitive for FH deficient leiomyomas?*
  • Alveolar edema
  • Nuclear palisading
  • Ovoid nuclei arranged in chains
  • Eosinophilic cytoplasmic inclusions and prominent nucleoli with perinucleolar halos.

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